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An Experimental and Computational Investigation of Spontaneous Lasso Formation in Microcin J25

The antimicrobial peptide microcin J25 (MccJ25) is posttranslationally matured from a linear preprotein into its native lasso conformation by two enzymes. One of these enzymes cleaves the preprotein and the second enzyme installs the requisite isopeptide bond to establish the lasso structure. Analys...

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Détails bibliographiques
Auteurs principaux: Ferguson, Andrew L., Zhang, Siyan, Dikiy, Igor, Panagiotopoulos, Athanassios Z., Debenedetti, Pablo G., James Link, A.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965945/
https://ncbi.nlm.nih.gov/pubmed/21044604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.08.073
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