Prognostic role of EGFR gene copy number and KRAS mutation in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy

BACKGROUND: Epidermal growth factor receptor (EGFR), evaluated by immunohistochemistry, has been shown to have prognostic significance in patients with colorectal cancer. Gene copy number (GCN) of EGFR and KRAS status predict response and outcome in patients treated with anti-EGFR therapy, but their...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Bengala, C, Bettelli, S, Bertolini, F, Sartori, G, Fontana, A, Malavasi, N, Depenni, R, Zironi, S, Del Giovane, C, Luppi, G, Conte, P F
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2010
Sujets:
Molecular Diagnostics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965865/
https://ncbi.nlm.nih.gov/pubmed/20842128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605853
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