A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

The activation of receptor tyrosine kinases, particularly ErbB2, plays an important role in the genesis of breast cancer. ErbB2 kinase activity promotes Ras-mediated stimulation of downstream protein kinase cascades, including the Ras/Raf-1/Mek/extracellular-signal regulated kinase (Erk) pathway, le...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Arias-Romero, Luis E., Villamar-Cruz, Olga, Pacheco, Almudena, Kosoff, Rachelle, Huang, Min, Muthuswamy, Senthil K., Chernoff, Jonathan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965784/
https://ncbi.nlm.nih.gov/pubmed/20711231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.318
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