A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

The activation of receptor tyrosine kinases, particularly ErbB2, plays an important role in the genesis of breast cancer. ErbB2 kinase activity promotes Ras-mediated stimulation of downstream protein kinase cascades, including the Ras/Raf-1/Mek/extracellular-signal regulated kinase (Erk) pathway, le...

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Bibliografiske detaljer
Main Authors: Arias-Romero, Luis E., Villamar-Cruz, Olga, Pacheco, Almudena, Kosoff, Rachelle, Huang, Min, Muthuswamy, Senthil K., Chernoff, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965784/
https://ncbi.nlm.nih.gov/pubmed/20711231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.318
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