Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects

Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular pathways critical for SMA pathology remain elusive. We have used genetic approaches in invertebrate models to identify conserved SMN loss of function modifier genes. Drosop...

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Hlavní autoři: Dimitriadi, Maria, Sleigh, James N., Walker, Amy, Chang, Howard C., Sen, Anindya, Kalloo, Geetika, Harris, Jevede, Barsby, Tom, Walsh, Melissa B., Satterlee, John S., Li, Chris, Van Vactor, David, Artavanis-Tsakonas, Spyros, Hart, Anne C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965752/
https://ncbi.nlm.nih.gov/pubmed/21124729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001172
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