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Highly Specific and Broadly Potent Inhibitors of Mammalian Secreted Phospholipases A(2)
We report a series of inhibitors of secreted phospholipases A(2) (sPLA(2)s) based on substituted indoles, 6,7-benzoindoles, and indolizines derived from LY315920, a well-known indole-based sPLA(2) inhibitor. Using the human group X sPLA(2) crystal structure, we prepared a highly potent and selective...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965735/ https://ncbi.nlm.nih.gov/pubmed/18605714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800422v |
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