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Biochemical Characterization of Selective Inhibitors of Human GIIA Secreted Phospholipase A(2) and Hyaluronic Acid-Linked Inhibitor Conjugates()
We explored the inhibition mode of group IIA secreted phospholipase A(2) (GIIA sPLA(2)) selective inhibitors and tested their ability to inhibit GIIA sPLA(2) activity as chemical conjugates with hyaluronic acid (HA). Analogs of a benzo-fused indole sPLA(2) inhibitor were developed where the carboxyl...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549043/ https://ncbi.nlm.nih.gov/pubmed/23020658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301140b |
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