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The First Potent Inhibitor of Mammalian Group X Secreted Phospholipase A(2): Elucidation of Sites for Enhanced Binding
Using the X-ray structure of human group X secreted phospholipase A(2) (hGX), we carried out structure-based design of indole-based inhibitors and prepared the compounds using a new synthetic route. The most potent compound inhibited hGX and the mouse orthologue with an IC(50) of 75 nM. This compoun...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963729/ https://ncbi.nlm.nih.gov/pubmed/16686528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060136t |
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