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Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats

BACKGROUND: It is well established that excessive consumption of a high fat diet (HFD) results in obesity; however, the consequences of obesity on postnatal skeletal development have not been well studied. METHODOLOGY AND PRINCIPAL FINDINGS: Total enteral nutrition (TEN) was used to feed postnatal d...

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Detalhes bibliográficos
Main Authors: Chen, Jin-Ran, Lazarenko, Oxana P., Wu, Xianli, Tong, Yudong, Blackburn, Michael L., Shankar, Kartik, Badger, Thomas M., Ronis, Martin J. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965663/
https://ncbi.nlm.nih.gov/pubmed/21060836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013704
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