Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I.

The functional heterogeneity of uridine diphosphate-glucuronosyltransferase (UDPGT) and its deficiency in human liver were investigated. The monoclonal antibody (MAb) WP1, which inhibits bilirubin and phenol-glucuronidating activity, was used to immunopurify UDPGTs from human liver. Purified UDPGTs...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: van Es, H H, Goldhoorn, B G, Paul-Abrahamse, M, Elferink, R P, Jansen, P L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296552/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2108190/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114553
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