Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I.

The functional heterogeneity of uridine diphosphate-glucuronosyltransferase (UDPGT) and its deficiency in human liver were investigated. The monoclonal antibody (MAb) WP1, which inhibits bilirubin and phenol-glucuronidating activity, was used to immunopurify UDPGTs from human liver. Purified UDPGTs...

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Publicado en:	J Clin Invest
Autores principales:	van Es, H H, Goldhoorn, B G, Paul-Abrahamse, M, Elferink, R P, Jansen, P L
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1990
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296552/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2108190/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114553
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