Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

Sirt1 has been associated with various effects of calorie restriction, including an increase in lifespan. Here we show in mice that a central regulatory component in energy metabolism, the hypothalamic melanocortin system, is affected by Sirt1, which promotes the activity and connectivity of this sy...

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Main Authors: Dietrich, Marcelo O., Antunes, Catiele, Geliang, Gan, Liu, Zhong-Wu, Borok, Erzsebet, Nie, Yongzhan, Xu, Allison W., Souza, Diogo O., Gao, Qian, Diano, Sabrina, Gao, Xiao-Bing, Horvath, Tamas L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965459/
https://ncbi.nlm.nih.gov/pubmed/20810901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2234-10.2010
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