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A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer
Lymphoid enhancer factor 1 (LEF-1) mediates Wnt signaling via recruitment of β-catenin to target genes. The LEF1 gene is aberrantly transcribed in colon cancers because promoter 1 (P1) is a Wnt target gene and is activated by TCF–β-catenin complexes. A second promoter in intron 2 (P2) produces domin...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965227/ https://ncbi.nlm.nih.gov/pubmed/20525792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq492 |
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