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Synthesis and characterization of oligodeoxyribonucleotides containing a site-specifically incorporated N(6)-carboxymethyl-2′-deoxyadenosine or N(4)-carboxymethyl-2′-deoxycytidine
Humans are exposed to both endogenous and exogenous N-nitroso compounds (NOCs), and many NOCs can be metabolically activated to generate a highly reactive species, diazoacetate, which is capable of inducing carboxymethylation of nucleobases in DNA. Here we report, for the first time, the chemical sy...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965219/ https://ncbi.nlm.nih.gov/pubmed/20507914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq458 |
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