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Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit

The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit.

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Bibliografiske detaljer
Main Authors: Boyle, Kristopher E., MacMillan, Karen S., Ellis, David A., Lajiness, James P., Robertson, William M., Boger, Dale L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965170/
https://ncbi.nlm.nih.gov/pubmed/20171886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.145
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