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Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice
MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary sequences in 3′ untranslated regions of target mRNAs. MicroRNA-21 (miR-21) is upregulated in response to cardiac stress, and its inhibition by a cholesterol-modified antagomir has been reported to prevent cardiac...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964990/ https://ncbi.nlm.nih.gov/pubmed/20978354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43604 |
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