Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary sequences in 3′ untranslated regions of target mRNAs. MicroRNA-21 (miR-21) is upregulated in response to cardiac stress, and its inhibition by a cholesterol-modified antagomir has been reported to prevent cardiac...

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Bibliografiske detaljer
Main Authors: Patrick, David M., Montgomery, Rusty L., Qi, Xiaoxia, Obad, Susanna, Kauppinen, Sakari, Hill, Joseph A., van Rooij, Eva, Olson, Eric N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2010
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964990/
https://ncbi.nlm.nih.gov/pubmed/20978354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43604
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