The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

US28 is a constitutively active chemokine receptor encoded by CMV (also referred to as human herpesvirus 5), a highly prevalent human virus that infects a broad spectrum of cells, including intestinal epithelial cells (IECs). To study the role of US28 in vivo, we created transgenic mice (VS28 mice)...

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Detalhes bibliográficos
Main Authors: Bongers, Gerold, Maussang, David, Muniz, Luciana R., Noriega, Vanessa M., Fraile-Ramos, Alberto, Barker, Nick, Marchesi, Federica, Thirunarayanan, Nanthakumar, Vischer, Henry F., Qin, Lihui, Mayer, Lloyd, Harpaz, Noam, Leurs, Rob, Furtado, Glaucia C., Clevers, Hans, Tortorella, Domenico, Smit, Martine J., Lira, Sergio A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964974/
https://ncbi.nlm.nih.gov/pubmed/20978345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42563
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