Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that has pleiotropic effects in a variety of cell types including ECs, SMCs, and macrophages, all of which are central to the development of atherosclerosis. It may therefore exert stimulatory and inhibitory effects on atheroscleros...

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Détails bibliographiques
Auteurs principaux: Wang, Fei, Okamoto, Yasuo, Inoki, Isao, Yoshioka, Kazuaki, Du, Wa, Qi, Xun, Takuwa, Noriko, Gonda, Koichi, Yamamoto, Yasuhiko, Ohkawa, Ryunosuke, Nishiuchi, Takumi, Sugimoto, Naotoshi, Yatomi, Yutaka, Mitsumori, Kunitoshi, Asano, Masahide, Kinoshita, Makoto, Takuwa, Yoh
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964972/
https://ncbi.nlm.nih.gov/pubmed/20978351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42315
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