Placental growth factor mediates aldosterone-dependent vascular injury in mice

In clinical trials, aldosterone antagonists reduce cardiovascular ischemia and mortality by unknown mechanisms. Aldosterone is a steroid hormone that signals through renal mineralocorticoid receptors (MRs) to regulate blood pressure. MRs are expressed and regulate gene transcription in human vascula...

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Main Authors: Jaffe, Iris Z., Newfell, Brenna G., Aronovitz, Mark, Mohammad, Najwa N., McGraw, Adam P., Perreault, Roger E., Carmeliet, Peter, Ehsan, Afshin, Mendelsohn, Michael E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964966/
https://ncbi.nlm.nih.gov/pubmed/20921624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40205
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