Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress-Dependent And –Independent Pathways

OBJECTIVE: Aldosterone (Aldo) antagonism prevents cardiovascular mortality by unclear mechanisms. Aldo binds to the mineralocorticoid receptor (MR), a ligand-activated transcription factor, which is expressed in human vascular cells. Here we define the early Aldo-regulated vascular transcriptome and...

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Autors principals: Newfell, Brenna G., Iyer, Lakshmanan K., Mohammad, Najwa N., McGraw, Adam P., Ehsan, Afshin, Rosano, Giuseppe, Huang, Paul L., Mendelsohn, Michael E., Jaffe, Iris Z.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141105/
https://ncbi.nlm.nih.gov/pubmed/21617142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.229070
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