Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication

Interferon alpha (IFN-α) binds to a cell surface receptor that activates the Jak-Stat signaling pathway. A critical component of this pathway is the translocation of interferon stimulated gene factor 3 (a complex of three proteins Stat1, Stat2 and IRF9) to the nucleus to activate antiviral genes. A...

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Hlavní autoři: Poat, Bret, Hazari, Sidhartha, Chandra, Partha K, Gunduz, Feyza, Alvarez, Xavier, Balart, Luis A, Garry, Robert F, Dash, Srikanta
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964675/
https://ncbi.nlm.nih.gov/pubmed/20939906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-7-265
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