Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion

The actin cross-linking protein filamin A (FLNa) functions as a scaffolding protein and couples cell cytoskeleton to extracellular matrix and integrin receptor signaling. In this study, we report that FLNa suppresses invasion of breast cancer cells and regulates focal adhesion (FA) turnover. Two lar...

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Main Authors: Xu, Yingjie, Bismar, Tarek A., Su, Jie, Xu, Bin, Kristiansen, Glen, Varga, Zsuzsanna, Teng, Lianghong, Ingber, Donald E., Mammoto, Akiko, Kumar, Rakesh, Alaoui-Jamali, Moulay A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964581/
https://ncbi.nlm.nih.gov/pubmed/20937704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100433
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