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Mechanisms of hypochlorite injury of target cells.

HOCl, which is produced by the action of myeloperoxidase during the respiratory burst of stimulated neutrophils, was used as a cytotoxic reagent in P388D1 cells. Low concentrations of HOCl (10-20 microM) caused oxidation of plasma membrane sulfhydryls determined as decreased binding of iodoacetylate...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Schraufstätter, I U, Browne, K, Harris, A, Hyslop, P A, Jackson, J H, Quehenberger, O, Cochrane, C G
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296458/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2153710/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114472
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