Role of oxidants in DNA damage. Hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke.

The mechanism by which cigarette smoking and asbestos exposure synergistically increase the incidence of lung cancer is unknown. We hypothesized that cigarette smoke and asbestos might synergistically increase DNA damage. To test this hypothesis we exposed isolated bacteriophage PM2 DNA to cigarette...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Jackson, J H, Schraufstatter, I U, Hyslop, P A, Vosbeck, K, Sauerheber, R, Weitzman, S A, Cochrane, C G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442351/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2821073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113165
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