Role of oxidants in DNA damage. Hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke.

The mechanism by which cigarette smoking and asbestos exposure synergistically increase the incidence of lung cancer is unknown. We hypothesized that cigarette smoke and asbestos might synergistically increase DNA damage. To test this hypothesis we exposed isolated bacteriophage PM2 DNA to cigarette...

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書誌詳細

出版年:	J Clin Invest
主要な著者:	Jackson, J H, Schraufstatter, I U, Hyslop, P A, Vosbeck, K, Sauerheber, R, Weitzman, S A, Cochrane, C G
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Clinical Investigation 1987
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442351/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2821073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113165
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