Mechanisms of hypochlorite injury of target cells.

HOCl, which is produced by the action of myeloperoxidase during the respiratory burst of stimulated neutrophils, was used as a cytotoxic reagent in P388D1 cells. Low concentrations of HOCl (10-20 microM) caused oxidation of plasma membrane sulfhydryls determined as decreased binding of iodoacetylate...

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Bibliographic Details
Main Authors: Schraufstätter, I U, Browne, K, Harris, A, Hyslop, P A, Jackson, J H, Quehenberger, O, Cochrane, C G
Format: Artigo
Language:Inglês
Published: 1990
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC296458/
https://ncbi.nlm.nih.gov/pubmed/2153710
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