Mechanisms of hypochlorite injury of target cells.

HOCl, which is produced by the action of myeloperoxidase during the respiratory burst of stimulated neutrophils, was used as a cytotoxic reagent in P388D1 cells. Low concentrations of HOCl (10-20 microM) caused oxidation of plasma membrane sulfhydryls determined as decreased binding of iodoacetylate...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Schraufstätter, I U, Browne, K, Harris, A, Hyslop, P A, Jackson, J H, Quehenberger, O, Cochrane, C G
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1990
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2153710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114472
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