Identification of the multiple beta-thalassemia mutations by denaturing gradient gel electrophoresis.

We used denaturing gradient gel electrophoresis to detect the beta-thalassemia mutations in the Chinese population. By amplifying the beta-globin gene in four separate fragments and electrophoresing the amplified DNA in two gels, we were able to distinguish all the 12 known mutations on the basis of...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Cai, S P, Kan, Y W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2298920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114471
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