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Identification of the multiple beta-thalassemia mutations by denaturing gradient gel electrophoresis.

We used denaturing gradient gel electrophoresis to detect the beta-thalassemia mutations in the Chinese population. By amplifying the beta-globin gene in four separate fragments and electrophoresing the amplified DNA in two gels, we were able to distinguish all the 12 known mutations on the basis of...

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Bibliografiske detaljer
Main Authors: Cai, S P, Kan, Y W
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC296457/
https://ncbi.nlm.nih.gov/pubmed/2298920
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