Identification of the multiple beta-thalassemia mutations by denaturing gradient gel electrophoresis.
We used denaturing gradient gel electrophoresis to detect the beta-thalassemia mutations in the Chinese population. By amplifying the beta-globin gene in four separate fragments and electrophoresing the amplified DNA in two gels, we were able to distinguish all the 12 known mutations on the basis of...
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| Udgivet i: | J Clin Invest |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
1990
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296457/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2298920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114471 |
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