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Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus.

We have studied several monoclonal anti-double-stranded (ds) DNA antibodies for their ability to accelerate lupus nephritis in young NZB X NZW F1 female mice and to induce it in BALB/c mice. Two identified as pathogens in both strains have characteristics previously associated with nephritogenicity:...

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Detalhes bibliográficos
Main Authors: Tsao, B P, Ebling, F M, Roman, C, Panosian-Sahakian, N, Calame, K, Hahn, B H
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC296455/
https://ncbi.nlm.nih.gov/pubmed/2129537
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