Adoptive transfer of EBV-specific T cells results in sustained clinical responses in patients with locoregional nasopharyngeal carcinoma

Patients with recurrent or refractory Epstein Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) continue to have poor outcomes. Our earlier Phase I dose escalation clinical study of 10 NPC patients showed that infusion of EBV-specific cytotoxic T cells (EBV-CTLs) was safe and had antitumor ac...

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Main Authors: Louis, Chrystal U, Straathof, Karin, Bollard, Catherine M, Ennamuri, Sravya, Gerken, Claudia, Lopez, Teresita T, Huls, M Helen, Sheehan, Andrea, Wu, Meng-Fen, Liu, Hao, Gee, Adrian, Brenner, Malcolm K, Rooney, Cliona M, Heslop, Helen E, Gottschalk, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964409/
https://ncbi.nlm.nih.gov/pubmed/20948438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181f3cbf4
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