Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients

Treatment of Epstein-Barr virus (EBV)–positive nasopharyngeal carcinoma (NPC) with EBV-specific cytotoxic T cells (EBV-specific CTL) has been promising, producing clinical responses. However, infused EBV-specific CTL did not expand in vivo, likely limiting their antitumor activity. Lymphodepleting p...

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Autores principales: Louis, Chrystal U., Straathof, Karin, Bollard, Catherine M., Gerken, Claudia, Huls, M. Helen, Gresik, M. Victoria, Wu, Meng-Fen, Weiss, Heidi L., Gee, Adrian P., Brenner, Malcolm K., Rooney, Cliona M., Heslop, Helen E., Gottschalk, Stephen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656271/
https://ncbi.nlm.nih.gov/pubmed/18971421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-157222
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