Antitumor Activity of EBV-specific T Lymphocytes Transduced With a Dominant Negative TGF-β Receptor

Transforming growth factor (TGF)-β is produced in most human tumors and markedly inhibits tumor antigen-specific cellular immunity, representing a major obstacle to the success of tumor immunotherapy. TGF-β is produced in Epstein-Barr virus (EBV)-positive Hodgkin disease and non-Hodgkin lymphoma bot...

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Main Authors: Foster, Aaron E., Dotti, Gianpietro, Lu, An, Khalil, Mariam, Brenner, Malcolm K., Heslop, Helen E., Rooney, Cliona M., Bollard, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745436/
https://ncbi.nlm.nih.gov/pubmed/18463534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e318177092b
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