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Non-Canonical NF-κB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3) activity. Ectopic expression of the fusion protein activates the canonical NF-κB sig...

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Autors principals: Conze, Dietrich B., Zhao, Yongge, Ashwell, Jonathan D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964333/
https://ncbi.nlm.nih.gov/pubmed/21048983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000518
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