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The balance between NF-κB p100 and p52 regulates T cell costimulation-dependence
c-IAP1 and c-IAP2 are ubiquitin protein ligases (E3s) that repress non-canonical NF-κB activation. We have created mice that bear a mutation in c-IAP2 that inactivates its E3 activity and interferes, in a dominant negative fashion, with c-IAP1 E3 activity (c-IAP2(H570A)). The immune response of thes...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538904/ https://ncbi.nlm.nih.gov/pubmed/23248260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201697 |
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