Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including s...

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Autori principali: Liu, Huiping, Patel, Manishkumar R., Prescher, Jennifer A., Patsialou, Antonia, Qian, Dalong, Lin, Jiahui, Wen, Susanna, Chang, Ya-Fang, Bachmann, Michael H., Shimono, Yohei, Dalerba, Piero, Adorno, Maddalena, Lobo, Neethan, Bueno, Janet, Dirbas, Frederick M., Goswami, Sumanta, Somlo, George, Condeelis, John, Contag, Christopher H., Gambhir, Sanjiv Sam, Clarke, Michael F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964232/
https://ncbi.nlm.nih.gov/pubmed/20921380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006732107
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