Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including s...

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Detalhes bibliográficos
Main Authors: Liu, Huiping, Patel, Manishkumar R., Prescher, Jennifer A., Patsialou, Antonia, Qian, Dalong, Lin, Jiahui, Wen, Susanna, Chang, Ya-Fang, Bachmann, Michael H., Shimono, Yohei, Dalerba, Piero, Adorno, Maddalena, Lobo, Neethan, Bueno, Janet, Dirbas, Frederick M., Goswami, Sumanta, Somlo, George, Condeelis, John, Contag, Christopher H., Gambhir, Sanjiv Sam, Clarke, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964232/
https://ncbi.nlm.nih.gov/pubmed/20921380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006732107
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