Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including s...

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主要な著者: Liu, Huiping, Patel, Manishkumar R., Prescher, Jennifer A., Patsialou, Antonia, Qian, Dalong, Lin, Jiahui, Wen, Susanna, Chang, Ya-Fang, Bachmann, Michael H., Shimono, Yohei, Dalerba, Piero, Adorno, Maddalena, Lobo, Neethan, Bueno, Janet, Dirbas, Frederick M., Goswami, Sumanta, Somlo, George, Condeelis, John, Contag, Christopher H., Gambhir, Sanjiv Sam, Clarke, Michael F.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2010
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964232/
https://ncbi.nlm.nih.gov/pubmed/20921380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006732107
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