Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT

Heat shock transcription factor 1 (HSF1) is an important regulator of protein homeostasis (proteostasis) by controlling the expression of major heat shock proteins (Hsps) that facilitate protein folding. However, it is unclear whether other proteostasis pathways are mediated by HSF1. Here, we identi...

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Main Authors: Hayashida, Naoki, Fujimoto, Mitsuaki, Tan, Ke, Prakasam, Ramachandran, Shinkawa, Toyohide, Li, Liangping, Ichikawa, Hitoshi, Takii, Ryosuke, Nakai, Akira
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964172/
https://ncbi.nlm.nih.gov/pubmed/20834230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.225
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