An interdomain sector mediating allostery in Hsp70 molecular chaperones

Allosteric coupling between protein domains is fundamental to many cellular processes. For example, Hsp70 molecular chaperones use ATP binding by their actin-like N-terminal ATPase domain to control substrate interactions in their C-terminal substrate-binding domain, a reaction that is critical for...

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Autores principales: Smock, Robert G, Rivoire, Olivier, Russ, William P, Swain, Joanna F, Leibler, Stanislas, Ranganathan, Rama, Gierasch, Lila M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964120/
https://ncbi.nlm.nih.gov/pubmed/20865007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.65
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