Synthetic Lethality Induced by Loss of PKC δ and Mutated Ras

Synthetic lethal interaction between oncogenic Ha-ras and loss of PKC has been demonstrated. Recently, the authors reported that the concurrent knockdown of PKC α and β, via upregulating PKC δ, sensitizes cells with aberrant Ras signaling to apoptosis. As a continuation of the study, using shRNA, th...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhu, Tongbo, Chen, Lihua, Du, Wei, Tsuji, Takanori, Chen, Changyan
Format: Artigo
Langue:Inglês
Publié: SAGE Publications 2010
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964089/
https://ncbi.nlm.nih.gov/pubmed/21031151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601909360989
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires