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Synthetic Lethality Induced by Loss of PKC δ and Mutated Ras
Synthetic lethal interaction between oncogenic Ha-ras and loss of PKC has been demonstrated. Recently, the authors reported that the concurrent knockdown of PKC α and β, via upregulating PKC δ, sensitizes cells with aberrant Ras signaling to apoptosis. As a continuation of the study, using shRNA, th...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
SAGE Publications
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964089/ https://ncbi.nlm.nih.gov/pubmed/21031151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601909360989 |
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