Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster

The hypothesis, that structural deterioration of cytochrome c oxidase (CcO) is a causal factor in the age-related decline in mitochondrial respiratory activity and an increase in H(2)O(2) generation, was tested in Drosophila melanogaster. CcO activity and the levels of seven different nuclear DNA-en...

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Bibliografiske detaljer
Main Authors: Ren, Jian-Ching, Rebrin, Igor, Klichko, Vladimir, Orr, William C., Sohal, Rajindar S.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964050/
https://ncbi.nlm.nih.gov/pubmed/20833144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.09.009
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