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A para-Amino Substituent on the D ring of Green Tea Polyphenol Epigallocatechin-3-gallate as a Novel Proteasome Inhibitor and Cancer Cell Apoptosis Inducer
Analogs of (-)-EGCG containing a para-amino group on the D ring in place of the hydroxyl groups have been synthesized and their proteasome inhibitory activities were studied. We found that, the O-acetylated (-)-EGCG analogs possessing a p-NH(2) or p-NHBoc (Boc; tert-butoxycarbonyl) D ring (5 and 7)...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963865/ https://ncbi.nlm.nih.gov/pubmed/17544279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.05.041 |
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