Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation

Heparan sulfate proteoglycans (HSPGs) play critical roles in the distribution and signaling of growth factors, but the molecular mechanisms regulating HSPG function are poorly understood. Here, we characterized Sulf1, which is a Drosophila member of the HS 6-O endosulfatase class of HS modifying enz...

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Bibliographic Details
Main Authors: Kleinschmit, Adam, Koyama, Takashi, Dejima, Katsufumi, Hayashi, Yoshiki, Kamimura, Keisuke, Nakato, Hiroshi
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963650/
https://ncbi.nlm.nih.gov/pubmed/20637191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.07.006
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