Analysis of Drosophila Glucuronyl C5-Epimerase: IMPLICATIONS FOR DEVELOPMENTAL ROLES OF HEPARAN SULFATE SULFATION COMPENSATION AND 2-O-SULFATED GLUCURONIC ACID

During the biosynthesis of heparan sulfate (HS), glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it to iduronic acid (IdoA). Because HS 2-O-sulfotransferase (Hs2st) shows a strong substrate preference for IdoA over GlcA, C5-epimerization is required f...

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Main Authors: Dejima, Katsufumi, Takemura, Masahiko, Nakato, Eriko, Peterson, Jesse, Hayashi, Yoshiki, Kinoshita-Toyoda, Akiko, Toyoda, Hidenao, Nakato, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Glycobiology and Extracellular Matrices
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843053/
https://ncbi.nlm.nih.gov/pubmed/24133213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.499269
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