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When the Optimal Is Not the Best: Parameter Estimation in Complex Biological Models

BACKGROUND: The vast computational resources that became available during the past decade enabled the development and simulation of increasingly complex mathematical models of cancer growth. These models typically involve many free parameters whose determination is a substantial obstacle to model de...

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Détails bibliographiques
Auteurs principaux: Fernández Slezak, Diego, Suárez, Cecilia, Cecchi, Guillermo A., Marshall, Guillermo, Stolovitzky, Gustavo
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963600/
https://ncbi.nlm.nih.gov/pubmed/21049094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013283
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