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The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin

Infection with human T-cell leukemia virus induces cellular genomic instability mediated through the viral oncoprotein Tax. Here we present evidence that Tax undermines the cellular DNA damage response by sequestration of damage response factors. We show by confocal microscopy that Tax forms damage-...

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Bibliografski detalji
Glavni autori: Belgnaoui, S. Mehdi, Fryrear, Kimberly A., Nyalwidhe, Julius O., Guo, Xin, Semmes, O. John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963403/
https://ncbi.nlm.nih.gov/pubmed/20729195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146373
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