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The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin

Infection with human T-cell leukemia virus induces cellular genomic instability mediated through the viral oncoprotein Tax. Here we present evidence that Tax undermines the cellular DNA damage response by sequestration of damage response factors. We show by confocal microscopy that Tax forms damage-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Belgnaoui, S. Mehdi, Fryrear, Kimberly A., Nyalwidhe, Julius O., Guo, Xin, Semmes, O. John
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963403/
https://ncbi.nlm.nih.gov/pubmed/20729195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146373
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