HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase

Human T-cell leukemia virus type-1 is the causative agent for adult T-cell leukemia. Previous research has established that the viral oncoprotein Tax mediates the transformation process by impairing cell cycle control and cellular response to DNA damage. We showed previously that Tax sequesters huCh...

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Detalhes bibliográficos
Main Authors: Durkin, Sarah S., Guo, Xin, Fryrear, Kimberly A., Mihaylova, Valia T., Gupta, Saurabh K., Belgnaoui, S. Mehdi, Haoudi, Abdelali, Kupfer, Gary M., Semmes, O. John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605996/
https://ncbi.nlm.nih.gov/pubmed/18957425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804931200
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