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Flexible Regions within IκBα Create the Ubiquitin-independent Degradation Signal
Homeostatic regulation of NF-κB requires the continuous synthesis of IκBα and its rapid degradation by the proteasome through a ubiquitin-independent pathway. We previously showed that the ubiquitin-independent degradation signal of unbound IκBα was located in the C-terminal PEST region, and we have...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963393/ https://ncbi.nlm.nih.gov/pubmed/20682784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.107326 |
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